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KMID : 0360220230640111055
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Journal of the Korean Ophthalmological Society
2023 Volume.64 No. 11 p.1055 ~ p.1062
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Changes in Macular Thickness and Microvasculature in Koreans with Early Parkinson’s Disease
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Rieko Tsuneta
Cho Yong-Wun
Kim Seong-Jae
Chung In-Young
Yoo Woong-Sun
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Abstract
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Purpose: To investigate the thickness of the nerve fiber layer-ganglion cell inner plexiform layer (NFL-GCIPL) complex and microvascular macular changes in Korean patients with early Parkinson’s disease using optical coherence tomography (OCT) and OCT angiography (OCTA).
Methods: Forty-three eyes of 22 patients with early Parkinson’s disease were included. A control group of 20 patients (40 eyes) was also recruited. The thickness of the NFL-GCIPL macular complex was measured using OCT, and the densities of the superficial and deep macular retinal vessels were evaluated via OCTA in all subjects.
Results: The NFL-GCIPL thicknesses of the superior, inferior, temporal, and nasal sectors were 94.70 ± 9.35, 93.32 ± 9.16, 90.18 ± 6.32, and 93.11 ± 8.75 μm in the control group and 92.05 ± 4.96, 91.32 ± 7.48, 84.74 ± 6.82, and 91.32 ± 7.47 μm in the Parkinson’s disease group, respectively; all thicknesses were significantly greater in the control group. The superficial and deep retinal vessel densities did not differ between the two groups.
Conclusions: Neurodegenerative macular changes are more obvious than microvascular changes in patients with early Parkinson’s disease. Such neurodegenerative changes should be further evaluated in future cohort studies.
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KEYWORD
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Neurodegeneration, Optical coherence tomography, Optical coherence tomography angiography, Parkinson’s disease
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